Sebanyak 575 item atau buku ditemukan

Aplastic Anemia and Other Bone Marrow Failure Syndromes

During the past decade, there have been numerous direct and indirect scientific contributions to both the etiology and therapy of aplastic anemia and related bone marrow failure syndromes. Clinical observations, such as autologous bone marrow recovery after conditioning with immunosup pressive agents for bone marrow transplantation; failure to achieve en graftment in some identical twins without prior immunosuppressive ther apy; and hematologic response to immunosuppressive agents, have led to the concept of immune-mediated etiology of acquired aplastic anemia. Such a concept was further strengthened by laboratory findings, implicat ing the role of activated cytotoxic T lymphocytes and abnormal produc tion of inhibitory lymphokines. The immunologic mechanisms may also apply to the idiosyncratic bone marrow aplasias associated with drugs, toxic chemicals, and viruses. These agents may alter normal cellular recog nition sites by interacting with cellular components and result in loss of self tolerance. Immunologic mechanisms have long been advocated in many other organ failures, and the hemopoietic organ is no exception. It is of interest that parallel clinical and laboratory investigations in juvenile diabetes mellitus type I and in rodent models of this disease have yielded results compatible with the same pathogenic mechanisms. The infiltration of pancreatic islets by activated T lymphocytes, functional and morphological alterations of islet cells upon incubation with lymphokines such as gamma interferon and tumor necrosis factor, and clinical response to cyclosporine are a few examples.

During the past decade, there have been numerous direct and indirect scientific contributions to both the etiology and therapy of aplastic anemia and related bone marrow failure syndromes.

Renal Anemia

Is the nephrology community facilitating excess cardiovascular deaths in patients with kidney failure and anemia by treating to a subnormal hematocrit? Why have clinicians and nephrologists permitted health insurance companies and the government to decide when anemia therapy should begin in persons with progressive kidney failure? Is iron the only variable that can be manipulated to maximize response to recombinant erythropoietin? Are we using too much intravenous iron in kidney failure patients, and is oral iron supplementation worthless in sustaining iron stores during long-term erythropoietin treatment? When does left ventricular hypertrophy begin to emerge in patients with progressive renal disease and is there convincing evidence that anemia is a significant cause of LVH in this setting? Is darbepoetin alfa, a new novel, long-acting erythropoietin, really superior to recombinant erythropoietin? This book is a compilation of proceedings from a conference in Brooklyn convened to address these and other controversial and unresolved issues in renal anemia management.

This book is a compilation of proceedings from a conference in Brooklyn convened to address these and other controversial and unresolved issues in renal anemia management.

Aplastic Anemia

Pathophysiology and Approaches to Therapy

Research on aplastic anaemia has until recently been limited to clinical description, morphology and epidemiology. New methods to culture haemopoietic cells, and advances in our knowledge of proliferation and differentiation in the haemopoietic cell system .opened a new area of scientific interest for this "prototype" of haemopoietic failure. In addition, bone marrow transplantation became not only a clinical method of treatment, but also a source of data useful for the discussion of pathophysiological models of aplastic anaemia. This situation prompted us to arrange an international con ference on aplastic anaemia, with particular emphasis on its patho physiology and the rationals of the current therapeutic approaches. This conference was held at Schloss Reisensburg from July 20-22, 1978 with the participation of both experimental and clinical scientists active in this field or in related areas of research. The proceedings of the symposion reflect the present knowledge as well as the many new questions which arose from the discussions. The editors are gratefully indebted to the participants of this meeting, to Gerlinde Trogele and all the co-workers of the Uni versity of Ulm engaged in preparation of this symposium and of this volume, and last not least to all sponsors who provided the financial basis for this scientific event.

The editors are gratefully indebted to the participants of this meeting, to Gerlinde Trogele and all the co-workers of the Uni versity of Ulm engaged in preparation of this symposium and of this volume, and last not least to all sponsors ...

Hemolytic Anemia in Disorders of Red Cell Metabolism

I am prepared to predict that this monograph by Dr. Ernest Beutler will long serve as a model for monographs dealing with topics in medical science. I make this bold statement because we encounter in this work a degree of accuracy and authoritativeness well beyond that found in much of the medical literature. Too often, a monograph is simply a review of past reviews. The preparation of an exhaustive and completely accurate study such as the present one is a very laborious task; consequently, many authors make extensive use of the reviews of earlier writers assum ing that the latter have checked and evaluated each previously published report. Unfortunately, however, this assumption of validity has not al ways been correct. Dr. Beutler, who is a world authority on the subject about which he writes, was determined to make this book as correct and complete as possible, and, to this end, has checked all the original sources. Nowhere else will such an exhaustive bibliography be found. Moreover, he has also undertaken to reevaluate in the light of current knowledge material pub lished in earlier days. This he is eminently able to do, and in some in stances his investigations have resulted in new interpretations. The result is a volume that will be recognized as truly the last word on this important subject.

I make this bold statement because we encounter in this work a degree of accuracy and authoritativeness well beyond that found in much of the medical literature. Too often, a monograph is simply a review of past reviews.

Fiqh al-Aqalliyy?t

History, Development, and Progress

This book examines the development of a contemporary internal debate among Muslim minorities living in Western Europe and North America to establish a specific form of Islamic jurisprudence. Fiqh al-aqalliyyat attempts to strike a balance between Muslim's religious commitments and their civic identity as citizens in Western liberal states.

Al-ʿAlwānī argues: We must inquire whether the ahadith have totally prohibited the making of images as an act of worship, or whether this prohibition is contextual. We must ask about that, which is critical in making proper Islamic ...

Data Analysis in Management with SPSS Software

This book provides readers with a greater understanding of a variety of statistical techniques along with the procedure to use the most popular statistical software package SPSS. It strengthens the intuitive understanding of the material, thereby increasing the ability to successfully analyze data in the future. The book provides more control in the analysis of data so that readers can apply the techniques to a broader spectrum of research problems. This book focuses on providing readers with the knowledge and skills needed to carry out research in management, humanities, social and behavioural sciences by using SPSS.

This book provides readers with a greater understanding of a variety of statistical techniques along with the procedure to use the most popular statistical software package SPSS.

Quantitative Analysis and IBM® SPSS® Statistics

A Guide for Business and Finance

This guide is for practicing statisticians and data scientists who use IBM SPSS for statistical analysis of big data in business and finance. This is the first of a two-part guide to SPSS for Windows, introducing data entry into SPSS, along with elementary statistical and graphical methods for summarizing and presenting data. Part I also covers the rudiments of hypothesis testing and business forecasting while Part II will present multivariate statistical methods, more advanced forecasting methods, and multivariate methods. IBM SPSS Statistics offers a powerful set of statistical and information analysis systems that run on a wide variety of personal computers. The software is built around routines that have been developed, tested, and widely used for more than 20 years. As such, IBM SPSS Statistics is extensively used in industry, commerce, banking, local and national governments, and education. Just a small subset of users of the package include the major clearing banks, the BBC, British Gas, British Airways, British Telecom, the Consumer Association, Eurotunnel, GSK, TfL, the NHS, Shell, Unilever, and W.H.S. Although the emphasis in this guide is on applications of IBM SPSS Statistics, there is a need for users to be aware of the statistical assumptions and rationales underpinning correct and meaningful application of the techniques available in the package; therefore, such assumptions are discussed, and methods of assessing their validity are described. Also presented is the logic underlying the computation of the more commonly used test statistics in the area of hypothesis testing. Mathematical background is kept to a minimum.

This guide is for practicing statisticians and data scientists who use IBM SPSS for statistical analysis of big data in business and finance.

Using SPSS for Windows

Data Analysis and Graphics

The second edition of this popular guide demonstrates the process of entering and analyzing data using the latest version of SPSS (12.0), and is also appropriate for those using earlier versions of SPSS. The book is easy to follow because all procedures are outlined in a step-by-step format designed for the novice user. Students are introduced to the rationale of statistical tests and detailed explanations of results are given through clearly annotated examples of SPSS output. Topics covered range from descriptive statistics through multiple regression analysis. In addition, this guide includes topics not typically covered in other books such as probability theory, interaction effects in analysis of variance, factor analysis, and scale reliability. Chapter exercises reinforce the text examples and may be performed for further practice, for homework assignments, or in computer laboratory sessions. This book can be used in two ways: as a stand-alone manual for students wishing to learn data analysis techniques using SPSS for Windows, or in research and statistics courses to be used with a basic statistics text. The book provides hands-on experience with actual data sets, helps students choose appropriate statistical tests, illustrates the meaning of results, and provides exercises to be completed for further practice or as homework assignments. Susan B. Gerber, Ph.D. is Research Assistant Professor of Education at State University of New York at Buffalo. She is director of the Educational Technology program and holds degrees in Statistics and Educational Psychology. Kristin Voelkl Finn, Ph.D. is Assistant Professor of Education at Canisius College. She teaches graduate courses in research methodology and conducts research on adolescent problem behavior.

This book can be used in two ways: as a stand-alone manual for students wishing to learn data analysis techniques using SPSS for Windows, or in research and statistics courses to be used with a basic statistics text.

E-Librarian Service

User-Friendly Semantic Search in Digital Libraries

This book introduces a new approach to designing E-Librarian Services. With the help of this system, users will be able to retrieve multimedia resources from digital libraries more efficiently than they would by browsing through an index or by using a simple keyword search. E-Librarian Services combine recent advances in multimedia information retrieval with aspects of human-machine interfaces, such as the ability to ask questions in natural language; they simulate a human librarian by finding and delivering the most relevant documents that offer users potential answers to their queries. The premise is that more pertinent results can be retrieved if the search engine understands the meaning of the query; the returned results are therefore logical consequences of an inference rather than of keyword matches. Moreover, E-Librarian Services always provide users with a solution, even in situations where they are unable to offer a comprehensive answer.

The key to understanding the breathtaking development of mankind lies in the
ability to objectify knowledge. Just like human knowledge has undergone
changes, so have the libraries in their role as treasure chambers of said
knowledge.

Integration and Innovation Orient to E-Society Volume 1

Seventh IFIP International Conference on e-Business, e-Services, and e-Society (I3E2007), October 10-12, Wuhan, China

The IFIP series publishes state-of-the-art results in the sciences and technologies of information and communication Proceedings and post-proceedings of referred international conferences in computer science and interdisciplinary fields are featured. These results often precede journal publication and represent the most current research. The principal aim of the IFIP series is to encourage education and the dissemination and exchange of information about all aspects of computing.

With the rapid development of the digital libraries, Interoperability is the problem
to realize the real information sharing and eliminate the digital information
islands. In this paper, the character and requirement of digital library
interoperability is ...